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PRP vs. PRF: What is the difference?

PRP vs. PRF: What is the difference?

PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) are both used in aesthetics as regenerative treatments, including at our medspa in downtown San Diego.

Here are the main differences:

Prepping PRP and PRF
With PRP, we centrifuge the patient’s blood sample at a high speed, which results in separating the plasma and platelet portion from the red and white blood cells.

PRF uses a lower centrifugation speed, which does not completely separate the platelets from the other blood components. This results in a fibrin matrix that contains platelets, white blood cells, and circulating stem cells.

Growth Factor Release
With PRP, the growth factors are released quickly after injection.
With PRF, the fibrin matrix releases growth factors over a longer period, providing a sustained effect that may enhance healing. 

How they are used
Both PRP and PRF are used for facial rejuvenation, hair growth, and improved healing of injuries or wounds. 

Effectiveness and Research
Both have shown effectiveness in promoting healing and regeneration. However, the research is ongoing, and there is no conclusively better treatment for aesthetic purposes. 

What to Expect:

Patients’ have let us know - short and long term results are noticeable and lasting from PRF and PRP with us at Vitality! Patients’ describe their appearance as more rested, supported, and less concealer/makeup is needed to love their look!


Vitality Aesthetics offers both PRF and PRP and our providers tailor the choice to the individual's needs and goals. We may recommend combining treatments with Morpheus8 or Sculptra treatment as well. 

Please contact us for a consultation regarding these wonderful regenerative treatments! 

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